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Pomegranate - Ellagic Acid

?What is Ellagic Acid?
  • Ellagic Acid is a naturally occurring polyphenolic constituent found in 46 different fruits and nuts, like pomegranate, red raspberry, strawberry, blueberry and walnuts.

  • Ellagic Acid is a nutraceutical.

  • Ellagic Acid contains a naturally occurring phenolic compound that has very strong anti-oxidant properties.

  • Ellagic Acid is also a potent anti-carcinogen.

  • Ellagic Acid has the ability to inhibit mutations within a cell's DNA.

  • Ellagic Acid is also considered to be a cancer inhibitor which has the ability to cause apoptosis or normal cell death in cancer cells.

  • In addition, research has found that Ellagic Acid has antibacterial and anti-viral properties.

  • Ellagic Acid may be one the most potent ways to fight Cancer!

  • Ellagic Acid may be one the most potent substances yet found to help prevent Cancer!

Simply put, clinical studies are showing that Ellagic Acid may be one of the most potent ways to prevent cancer, inhibit the growth of cancer cells, and arrest the growth of cancer in subjects with a genetic predisposition for the disease.

The Hollings Cancer Institute at the University of South Carolina is conducting a double blind study on a group of 500 cervical cancer patients that has everyone excited. Nine years of study have shown that a natural product called Ellagic Acid is causing G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division), and apoptosis (normal cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer cells.

Ellagic Acid has been demonstrated in animal models to inhibit tumor growth caused by carcinogens. Other studies have also found positive effects. A recent animal study found that ellagic Acid protected mice against chromosome damage from radiation therapy. A separate study of ellagic Acid indicated that it was effective at inhibiting tumor growth from esophageal cancer cells in mice.

If we consider all the ramifications of the current cancer pandemic and the dismal failure rate of the traditional methods of treatment, then we may start to realize that nutraceuticals, such as Ellagic Acid, may hold the key to millions of successful outcomes for cancer sufferers.

Pomegranate is a great source of potassium, vitamin C and polyphenols, which promote heart health. Pomegranates also contain high levels of flavonoids, potent antioxidants, which may offer protection against heart disease and cancer. A glass of pomegranate juice has more antioxidants than do red wine, green tea, cranberry juice and orange juice. According to a study reported in the American Journal of Clinical Nutrition, people who drank just 2 oz. a day for a week showed an average increase of 9% in antioxidant activity. And in a study presented at an American Association for Cancer Research conference last month, researchers found that pomegranate extract may help fight skin cancer.


The lovely and delicious pomegranate fruit reminds us of the lush gardens of Andalucia, Spain. The name comes from Pomme de Granada, "apple of Granada" it was thought to have originated there. Granada's coat-of-arms still displays the picture of this exotic fruit. In ancient times, pomegranate fruit was regarded as a symbol of fertility due to the round shape, and abundant seeds. Recently however, science has discovered important compounds, which indicate its benefits, transcend ancient symbolism.

Pomegranate extract is primarily composed of alkaloids and polyphenols. The active constituent that appears to be responsible for its multiple health benefits is Ellagic acid. Ellagic acid is a naturally occurring phenolic compound found in several fruits and nuts. Pomegranate extract has demonstrated a variety of beneficial functions including antioxidant and anti-viral activity. In 1996, a Nottingham, PA University research team learned that pomegranate extract could destroy several viruses nearly on contact. The discovery of this anti-viral activity instigated further experimentation and clinical trials. One study confirmed that Ellagic acid effectively protects cells from damaging free radicals. Additional phenolic compounds found in pomegranate known as anthocynadins (also well known scavengers of free radicals) combine synergistically with Ellagic acid to greatly augment pomegranate's potency as an antioxidant.

Of great importance is the pomegranate extracts potential use as a chemo-preventive agent. Initial experimentation by Stoner and Mukhtar showed that Ellagic acid decreased the number of chemically induced lung tumors by 44-75%. Mukhtar further illustrated that topical application of Ellagic acid provided protection against chemically induced skin tumors.
Ellagic acid has several mechanisms of actions by which it exhibits its chemo-preventive properties. Research by Barch et al. Demonstrated that Ellagic acid could actually bind to DNA, thus preventing its carcinogenic alteration. Additionally, Ellagic acid has been shown to induce the production of phase 11 detoxification enzymes through its manipulation of gene expression. With an increased concentration of these enzymes, various tissues ability to detoxify harmful compounds is augmented. Finally, Ellagic acid was found to be a potent inhibitor of tyrosine protein kinase, a molecule whose activity has been associated with the ability of certain viruses to transform normal cells into cancerous cells.

Science News

Pomegranate juice confers cardiovascular health benefits

In vivo studies in healthy nonsmoking men and mice with experimentally induced atherosclerosis (hardening of the arteries) concluded that pomegranate (Punica granatum)
had potent antiatherogenic effects, possibly due its antioxidant activity. In the men, consumption of pomegranate decreased the susceptibility of low-density lipoprotein (LDL) cholesterol to aggregation and retention, and increased the activity of serum paraoxonase (a naturally occurring antioxidant) by 20%. In mice, pomegranate reduced oxidation of LDL by 90%. In addition, pomegranate shrank atherosclerotic lesions in the mice by 44%, compared with control mice. Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice.

The above information is not intended to treat, diagnose, cure or prevent any disease. If you are having serious problems, consult your healthcare provider at once

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